Adverse Drug Reactions from

Adverse drug reactions, (ADRs) usually called side effects, are a long-standing and largely neglected major medical problem. These are not medical errors and occur within the FDA approved dosage and labeling recommendations. The recently reported problems with antidepressant induced teen suicides, the recalls of Vioxx and Baycol and the upgrading of Accutane monitoring by the FDA are the tip of the iceberg.

Incidence of Adverse Drug Reactions

Financial Consequences

Potential of Pharmacogenetic DNA Drug Reaction Testing to reduce ADRs and save money.

Some examples of studies pointing out the results of adverse drug reactions.

Why adverse drug reactions are a growing problem.

The 1992 Prescription Drug User Fee Act requiring drug companies to pay "user fees" to fund the FDA in order to accelerate the drug approval process. None of the $825 million in user fees collected from 1993 to 2001 can be used for drug safety or post marketing surveys.

Adverse drug reactions in the elderly.

Elderly patients have a decreased capacity to detoxify drugs they are taking. Drug drug interactions are also an important contributor to adverse drug reactions which makes the aging population vulnerable because of the large number of drugs they are taking.

Adverse drug reactions in children and adolescents.

Few drugs are tested in children prior to release. Many are used off label in pediatric populations. For example, only Prozac (fluoxetine) has been approved for use in children, yet many others are prescribed off label.

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